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American Association for Cancer Research

Vaccine against HER2-positive breast cancer offers complete protection in lab

Published in Cancer Weekly, September 30th, 2008

Researchers at Wayne State University have tested a breast cancer vaccine they say completely eliminated HER2-positive tumors in mice - even cancers resistant to current anti-HER2 therapy - without any toxicity.

The study, reported in the September 15 issue of Cancer Research, a journal of the American Association for Cancer Research, suggests the vaccine could treat women with HER2-positive, treatment-resistant cancer or help prevent cancer recurrence. The researchers also say it might potentially be used in cancer-free women to prevent initial development of these tumors.

HER2 receptors promote normal cell growth, and are found in low amounts on...

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