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Adenomatous Polyposis Coli
Research from University of Tokyo in the area of adenomatous polyposis coli described
September 30th, 2008
According to a study from Tokyo, Japan, "Numerous independent clinical and experimental studies indicate that estrogens confer a protective effect against development of intestinal tumors, however the molecular mechanisms involved remain unclear. Physiological effects of estrogens are predominantly mediated by the action of nuclear estrogen receptors (ERs)." "A multifunctional protein adenomatous polyposis coli (APC) is a tumor suppressor and thought to act as a gatekeeper in colon tumorigenesis, as loss of function APC mutations trigger the development of colorectal cancer. Here we report that APC physically associates with ER alpha in the ligand-dependent manner. We...
Source: Cancer Weekly (2008-09-30)
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