Hepatocellular Cancer

Reports from National Taiwan University add new data to research in hepatocellular cancer

Published in Cancer Weekly, September 30th, 2008

"Bortezomib, a proteasome inhibitor, has been clinically approved for the treatment of myeloma and lymphoma. Here, we report a differential effect of bortezomib on apoptosis in four hepatocellular carcinoma (HCC) cell lines and identify the major molecular event that determines sensitivity," researchers in Taipei, Taiwan report.

"Although bortezomib inhibited proteasome activity to a similar extent in all HCC cell lines, it showed differential effects on their viability: Hub-7 (IC50 196 nmol/L), Sk-Hep1 (IC50 180 nmol/L), Hep3B (IC50 112 nmol/L), and resistant PLC5 (IC50 > 1,000 nmol/L). Bortezomib caused cell cycle arrest at G(2)-M phase in all HCC cells tested...

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Source: Cancer Weekly (2008-09-30)

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