Cancer Weekly
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Apoptosis
Research from Virginia Commonwealth University, Medical Department broadens understanding of apoptosis
September 30th, 2008
"Reactive oxygen species (ROS) and resultant oxidative damage is a common pathway for gastric mucosal injury. This study was undertaken to determine whether apoptosis or necrosis was responsible for hydrogen peroxide (a representative ROS)-induced gastric mucosal death and whether caspase cascade blockade could prevent this process," scientists in the United States report. "AGS cells (human gastric adenocarcinoma cells) were exposed to hydrogen peroxide (H2O2), 0.5-2 mM, from 6 to 24 h. Lactic dehydrogenase (LDH) measured necrosis, whereas Caspase-3 and PARP activation and DNA-histone complex formation measured apoptosis. In addition, AGS cells received no pretreatment...
Source: Cancer Weekly (2008-09-30)
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