Cancer Weekly
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Bladder Cancer
Data from D. Ahirwar et al provide new insights into bladder cancer
September 30th, 2008
According to recent research from Lucknow, India, "Cytokines mediate many immune and inflammatory responses contributing to tumorigenesis. The present study evaluated polymorphisms of IL4, IL6, and TNF (previously TNFA) genes influencing risk in development of transitional cell carcinoma of bladder and recurrence after bacillus Calmette-Guerin (BCG) immunotherapy." "The study included 136 unrelated histopathologically confirmed cases and 200 population-based controls. Genomic DNA was extracted from peripheral leukocytes and genotyped for polymorphism in IL4 intron 3, with point mutations identified by amplification refractory mutation system polymerase chain reaction...
Source: Cancer Weekly (2008-09-30)
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