Cancer Weekly
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Breast Cancer
Data on breast cancer reported by researchers at King Abdul-Aziz University
September 30th, 2008
According to recent research from Jeddah, Saudi Arabia, "Purpose 2-Methoxyestradiol (2ME), an endogenous estradiol metabolite, was developed as a novel agent based on its antitumor activity and lack of toxicity. This study was designed to investigate the modulatory effect of 2ME on the antitumor effect of doxorubicin (Dox) in resistant breast tumor xenograft." "Resistant MCF-7/Dox cells were implanted subcutaneously in nude mice Methods Treatment with Dox 5 mg/kg, 2ME 30 mg/kg and their combination continued twice a week for 2 weeks. Following 28 days from starting the treatment with Dox alone, the change in tumor volume from first day of treatment was 455.6 +/- 16.2%....
Source: Cancer Weekly (2008-09-30)
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