Cancer Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Cancer Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Breast Cancer
Recent findings from University of Toulouse highlight research in breast cancer
September 30th, 2008
"In breast cancer, approximately one-third of tumors express neither the estrogen receptor ( ER alpha) nor estrogen-regulated genes such as the progesterone receptor gene ( PR). Our study provides new insights into the mechanism allowing hormone-activated expression of ER alpha target genes silenced in ER alpha-negative mammary tumor cells," researchers in Toulouse, France report. "In cell lines derived from ER alpha-negative MDA-MB231 cells, stable expression of different levels of ER alpha from a transgene did not result in transcription of PR. A quantitative comparative analysis demonstrates that inhibiting DNA methyltransferases using 5-aza-2 '-deoxycytidine or...
Source: Cancer Weekly (2008-09-30)
|
