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HIV/AIDS
Study findings from Columbus Children's Hospital broaden understanding of HIV/AIDS
October 7th, 2008
According to a study from the United States, "The host factor a isoform of the tripartite motif 5 (TRIM5 alpha) restricts human immunodeficiency virus type 1 (HIV-1) infection in certain non-human primate species. Restriction of HIV-1 is enhanced by binding of the viral capsid to cyclophilin A ( CypA) in target cells, although CypA is not absolutely required for restriction in rhesus macaque cells." "Simian immunodeficiency virus (SIV) is not restricted by rhesus macaque TRIM5a and its capsid does not bind to CypA. Here, the effect of lentiviral CypA dependence on restriction in different tissues was examined by engineering an HIV-1 capsid quadruple mutant...
Source: Cancer Weekly (2008-10-07)
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