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Cancer Gene Therapy
Reports outline cancer gene therapy research from Seoul National University, Department of Biology
October 7th, 2008
Current study results from the report, 'ATR-dependent activation of p38 MAP kinase is responsible for apoptotic cell death in cells depleted of Cdc7,' have been published. According to a study from Seoul, Korea, "Cdc7 is a serine/threonine kinase that plays essential roles in the initiation of eukaryotic DNA replication and checkpoint response. In previous studies, depletion of Cdc7 by small interfering RNA was shown to induce an abortive S phase that led to the cell cycle arrest in normal human fibroblasts and apoptotic cell death in various cancer cells." "Here we report that stress-activated p38 MAP kinase was activated and responsible for apoptotic cell death in...
Source: Cancer Weekly (2008-10-07)
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