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Cancer Weekly

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Cancer Gene Therapy



Research results from Queen's University, Center for Cancer Research and Cell Biology update knowledge of cancer gene therapy



October 7th, 2008

New research, 'Interleukin-8 signaling attenuates TRAIL- and chemotherapy-induced apoptosis through transcriptional regulation of c-FLIP in prostate cancer cells,' is the subject of a report. According to recent research published in the journal Molecular Cancer Therapeutics, "Chemotherapy-induced interleukin-8 (IL-8) signaling reduces the sensitivity of prostate cancer cells to undergo apoptosis. In this study, we investigated how endogenous and drug-induced IL-8 signaling altered the extrinsic apoptosis pathway by determining the sensitivity of LNCaP and PC3 cells to administration of the death receptor agonist tumor necrosis factor-related apoptosis-inducing ligand...


Source: Cancer Weekly (2008-10-07)

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