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Cancer Weekly

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Life Sciences



Researchers from Dongguk University, Department of Biochemistry discuss findings in life sciences



October 7th, 2008

New investigation results, 'Combination therapy and noninvasive imaging with a dual therapeutic vector expressing MDR1 short hairpin RNA and a sodium iodide symporter,' are detailed in a study published in Journal of Nuclear Medicine. "We investigated the feasibility of using combination gene therapy and noninvasive nuclear imaging after expression of the human sodium iodide symporter (hNIS) and inhibition of the multidrug resistance (MDR1) gene in colon cancer cells. HCT-15 cells were stably transfected with a dual expression vector, in which the hNIS gene, driven by a constitutive cytomegalovirus promoter, has been coupled to an MDR1 short hairpin RNA (shRNA) cassette,"...


Source: Cancer Weekly (2008-10-07)

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