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Angiogenesis
Reports outline angiogenesis research from University of Wisconsin
October 7th, 2008
"Hypoxia-inducible factor-1 alpha (HIF-1 alpha) and aryl hydrocarbon receptor nuclear translocator (ARNT) are basic helix-loop-helix/per-arnt-sim (PAS) family transcription factors. During angiogenesis and tumor growth, HIF-1 alpha dimerizes with ARNT, inducing expression of many genes, including vascular endothelial growth factor (VEGF)," scientists writing in the journal Carcinogenesis report. "ARNT also dimerizes with the aryl hydrocarbon receptor (AhR). AhR-null (Ahr(-/-)) transgenic adenocarcinoma of the mouse prostate (TRAMP) mice develop prostate tumors with greater frequency than AhR wild-type (Ahr(+/+)) TRAMP mice, even though prevalence of prostate...
Source: Cancer Weekly (2008-10-07)
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