Cancer Weekly
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Apoptosis
Researchers from University of Pittsburgh, Medical Department publish findings in apoptosis
October 7th, 2008
According to recent research from the United States, "FADD/MORT1 (The adaptor protein of Fas Associate Death Domain/Mediator of Receptor Induced Toxicity) is essential for signal transduction of death receptor signaling. We have previously shown that FADD is significantly up-regulated in TNF alpha/ActD induced apoptosis." "Over-expression of FADD also induces death of lung cancer cells and primary hepatocytes. We hypothesize that the increase in detectable FADD levels require the proximal steps in apoptotic signaling and speculated that FADD would be redistributed in cells destined to undergo apoptosis. We show that monomeric non-phosphorylated FADD is up-regulated in...
Source: Cancer Weekly (2008-10-07)
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