Cancer Weekly
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Arthritis
Studies from University of Calgary in the area of arthritis described
October 7th, 2008
"Proteinases such as thrombin and trypsin can affect tissues by activating a novel family of G protein-coupled proteinase-activated receptors (PARs 1-4) by exposing a 'tethered' receptor-triggering ligand (TL). Work with synthetic TL-derived PAR peptide sequences (PAR-APs) that stimulate PARs 1, 2 and 4 has shown that PAR activation can play a role in many tissues, including the gastrointestinal tract, kidney, muscle, nerve, lung and the central and peripheral nervous systems, and can promote tumor growth and invasion," scientists in Calgary, Canada report. "PARs may play roles in many settings, including cancer, arthritis, asthma, inflammatory bowel disease,...
Source: Cancer Weekly (2008-10-07)
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