Cancer Weekly
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Biopsy
Research conducted at Harvard University, Medical Department has provided new information about biopsy
October 7th, 2008
"Topoisomerase II alpha and minichromosome maintenance protein 2 are proteins associated with aberrant S-phase induction. The current study evaluated the performance of these biomarkers (ProExt (TM) C; TriPath Oncology, Burlington, NC) compared with p16(INK4A) and MiB-1 in distinguishing high-grade squamous intraepithelial lesions (HSILs) from HSIL mimics," researchers in the United States report. "We collected archival cervical biopsy, cone, and curettage specimens from 96 cases in which the differential diagnosis of HSIL vs reactive epithelial changes was considered. Hematoxylin and eosin-stained slides were reviewed independently by three pathologists and scored for...
Source: Cancer Weekly (2008-10-07)
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