Cancer Weekly
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Cancer Vaccines
Studies from St. James University in the area of cancer vaccines published
October 14th, 2008
According to recent research from Leeds, the United Kingdom, "The immune response to cancer is critically determined by the way in which tumor cells die. As necrotic, stress-associated death can be associated with activation of antitumor immunity, whole tumor cell antigen loading strategies for dendritic cell (DC)-based vaccination have commonly used freeze-thaw ''necrotic'' lysates as an immunogenic source of tumor-associated antigens." "In this study, the effect of such lysates on the ability of DCs to mature in response to well-established maturation stimuli was examined, and methods to enhance lysate-induced DC activation explored. Freeze-thaw lysates were prepared...
Source: Cancer Weekly (2008-10-14)
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