Colon Cancer
Findings from University of Shizuoka in colon cancer reported
Published in Cancer Weekly, October 14th, 2008
According to recent research published in the Journal of Nutritional Science and Vitaminology, "It is reported that arachidonic acid strongly induces the conformational change in vitro and transactivity of PPAR alpha in colorectal cancer cell line Caco-2. In this Study. we demonstrated that the induction of conformational change and transactivity of PPAR delta by arachidonic acid. as well as other polyunsaturated fatty acids, was considerably lower than that of PPAR alpha."
"Mammalian two-hybrid assay showed that arachidonic acid enhanced binding of one of the coactivators. p300, to PPAR alpha but not to PPAR delta. Additionally, arachidonic acid induced in vitro...
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Source: Cancer Weekly (2008-10-14)
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