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Gene Therapy
Researchers from Catholic University, Cell Therapy Center provide details of new studies and findings in the area of gene therapy
October 14th, 2008
"Low in vivo transduction efficiency and safety concerns have been hurdles for effective hematopoietic stem cell (HSC) gene therapy. Here, we investigate whether the safety and efficiency of retroviral gene transfer into HSCs can be improved by using human allogeneic umbilical cord blood (UCB)-derived supplements instead of fetal bovine serum (FBS)," investigators in Seoul, South Korea report. "When CD34(+) cells were cultured ex vivo in UCB-derived serum (CBS) or plasma (CBP), comparable or higher maintenance of HSCs was observed than in FBS and serum-free substitution medium (SFM) as assessed by the frequency of positive engraftment and the level of engraftment in...
Source: Cancer Weekly (2008-10-14)
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