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Acute Myeloid Leukemia
New acute myeloid leukemia study findings have been reported by researchers at Juntendo University, Medical Department
October 14th, 2008
"We report a novel three-way translocation involving inversion 16 and chromosome 12 at bands 16p13, 16q22, and 12q24 in a patient with therapy-related acute myeloid leukemia (AML)-M4eo. Conventional G-banding of bone marrow cells at diagnosis was suggestive of inv(16)(p13q22) and a translocation of chromosomes 12 and 16," investigators in Hongo, Japan report. "The presence of inv(16) was confirmed by reverse-transcription polymerase chain reaction (RT-PCR) analysis, which corresponded to the type A CBFB-MYH11 chimeric transcript. Spectral karyotyping (SKY) analysis clearly identified a reciprocal translocation between chromosomes 12 and 16. In addition, dual-color...
Source: Cancer Weekly (2008-10-14)
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