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Angiogenesis
Reports outline angiogenesis study findings from Medical College of Wisconsin, Medical College
October 14th, 2008
"Cytochrome P450 epoxygenase catalyzes 5,6-, 8,9-, 11,12-, and 14,15- epoxyeicosatrienoic acids ( EETs) from arachidonic acid ( AA). In 1996, our group identified the expression of the cytochrome P450 2C11 epoxygenase ( CYP epoxygenase) gene in astrocytes," scientists writing in the Journal of Cerebral Blood Flow and Metabolism report. "Because of our finding an array of physiological functions have been attributed to EETs in the brain, one of the actions of EETs involves a predominant role in brain angiogenesis. Blockade of EETs formation with different epoxygenase inhibitors decreases endothelial tube formation in cocultures of astrocytes and capillary...
Source: Cancer Weekly (2008-10-14)
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