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Bone Research
New bone research findings from University of Antwerp published
October 14th, 2008
According to a study from Antwerp, Belgium, "Low-density lipoprotein receptor-related protein 5 (LRP5), a Wnt coreceptor, plays an important role in bone metabolism as loss-of-function and gain-of-function mutations in LRP5 result in the autosomal recessive osteoporosis-pseudoglioma syndrome and amosomal dominant high-bone mass (HBM) phenotypes, respectively. Prior studies suggested that the presence of HBM-associated LRP5 mutations results in decreased antagonism of LRP5mediated Wnt signaling." "In the present study, we investigated six different HBM-LRP5 mutations and confirm that neither Dickkopfl (DKKI) nor sclerostin efficiently inhibits HBM-LRP5 signaling. In...
Source: Cancer Weekly (2008-10-14)
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