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Bone Research
Study results from University of Melbourne update understanding of bone research
October 14th, 2008
"With the aim of identifying new pathways and genes regulated by PTH(1-34) and PTH-related protein 1-141 [PTHrP(1-141)] in osteoblasts, this study was carried out using a mouse marrow stromal cell line, Kusa 4b10, that acquires features of the osteoblastic phenotype in long-term culture conditions. After the appearance of functional PTH receptor 1 (PTHR1) in Kusa 4b10 cells, they were treated with either PTH(134) or PTHrP(1-141), and RNA was subjected to Affymetrix whole mouse genome array," scientists in Fitzroy, Australia report. "The microarray data were validated using quantitative real-time RT-PCR on independently prepared RNA samples from differentiated Kusa 4b10,...
Source: Cancer Weekly (2008-10-14)
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