Cancer Gene Therapy

Studies from M.M.B. Rodriguez et al add new findings in the area of cancer gene therapy

Published in Cancer Weekly, October 14th, 2008

"Most hepatocellular carcinomas (HCCs) express oncofetal alpha-fetoprotein (AFP). We and others have demonstrated efficient tumor control mediated by cellular immune responses in mice bearing subcutaneous tumors derived from the AFP-expressing murine HCC cell line Hepa 1-6 by DNA vaccination against AFP," scientists in Lahr, Germany report.

"In the present study, we examined AFP DNA vaccination in the AFP-expressing primary murine HCC model BW7756. In this model AFP DNA vaccination resulted in only minimal lymphocytic infiltration and failed to control tumor growth. To augment the AFP-specific cellular immune response, intratumoral expression of chemokine IP-10...

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Source: Cancer Weekly (2008-10-14)

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