Cancer Weekly
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Gene Therapy
Research data from F. Benjelloun and colleagues update understanding of gene therapy
October 21st, 2008
According to a study from Paris, France, "Patients with mutations in the Artemis gene display a complete absence of T-and B lymphocytes, together with increased cellular radiosensitivity; this leads to a radiosensitive severe combined immunodeficiency (RS-SCID). Allogenic hematopoietic stem-cell (HSC) transplantation is only partially successful in the absence of an human leukocyte antigen-genoidentical donor, and this has prompted a search for alternative therapeutic approaches such as gene therapy." "In this study, a self-inactivated lentiviral vector expressing Artemis was used to complement the Artemis knockout mouse (Art(-/-)). Transplantation of Artemis-transduced...
Source: Cancer Weekly (2008-10-21)
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