Myeloma
Study findings from B.J. Taylor et al provide new insights into myeloma
Published in Cancer Weekly, October 21st, 2008
"Multiple myeloma (MM) is a cancer of plasma cells (PCs) expressing immunoglobulin heavy chain (IgH) postswitch isotypes. The discovery of earlier stage cells related to postswitch PCs, called preswitch clonotypic IgM (clgM) cells led to the hypothesis that clgM cells may be MM progenitors, replenishing the tumor throughout malignancy. clgM cells may do this by undergoing class switch recombination (CSR), a process detectable in postswitch PCs as multiple IgH switch junctions associated with a single clonotypic IgH V/D/J," investigators in Edmonton, Canada report.
"We addressed this with a specific clonotypic-switch polymerase chain reaction (PCR), informative for 32 of...
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Source: Cancer Weekly (2008-10-21)
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