Cancer Weekly
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Acute Myeloid Leukemia
Research by S.P. Whitman and colleagues in acute myeloid leukemia provides new insights
October 21st, 2008
According to recent research from the United States, "Posttranslationally modified histones and DNA hypermethylation frequently interplay to deregulate gene expression in cancer. We report that acute myeloid leukemia (AML) with an aberrant histone methyltransferase, the mixed lineage leukemia partial tandem duplication (MLL-PTD), exhibits increased global DNA methylation versus AML with MLL-wildtype (MLL-WT-, P =.02)." "Among the differentially methylated genes, the SLC5A8 tumor suppressor gene (TSG) was more frequently hypermethylated (P =.003). In MLL-PTD+ cell lines having SLC5A8 promoter hypermethylation, incubation with decitabine activated SLC5A8 expression....
Source: Cancer Weekly (2008-10-21)
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