Cancer Weekly
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Acute Myeloid Leukemia
Research on acute myeloid leukemia reported by K.P. Huang et al
October 21st, 2008
"The rare recurrent translocation of (8;9)(p22;p24) with PCM1-JAK2 fusion was recently characterized in diverse hematological malignancies. Most of them are atypical chronic myeloid leukemia (CML) or other myeloproliferative disorders (MPD), and are predominantly in the male," investigators in Hualien, Taiwan report. "We report a female patient with acute myeloid leukemia (AML) initially presenting with normal karyotype and negative HLA-DR expression who achieved complete remission after standard chemotherapy. The disease relapsed 7 months later with cytogenetic change of t(8;9)(p22;p24). Flow cytometry analysis showed evolutional change of immunophenotype from negative...
Source: Cancer Weekly (2008-10-21)
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