Cancer Gene Therapy

New findings from Johns Hopkins University, Medical Department in the area of cancer gene therapy published

Published in Cancer Weekly, October 21st, 2008

"Multimodality treatments that combine conventional cancer therapies with antigen- specific immunotherapy have emerged as promising approaches for the control of cancer. In the current study, we have explored the effect of doxorubicin on the antigen- specific immune responses generated in mice vaccinated with calreticulin (CRT)/E6 and/or Ii-PADRE DNA," researchers in the United States report.

"We observed that pretreatment with doxorubicin suppressed the E6-specific CD8(+) T-cell immune responses generated by CRT/E6 DNA vaccination in vaccinated mice. In contrast, pretreatment with doxorubicin enhanced the PADRE-specific CD4(+) T-cell immune responses generated by...

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Source: Cancer Weekly (2008-10-21)

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