Investigators publish new data in the report 'An immunotolerant HER-2/neu transgenic mouse model of metastaticbreast cancer.' "Animal models of breast cancer metastases that recapitulate the pattern of metastatic progression seen in patients are lacking; metastatic breast cancer models do not currently exist for evaluation of immune-mediated therapies. We have developed and characterized a preclinical model for the evaluation of immune-mediated metastatic breast cancer therapies," researchers in the United States report.
"The NT2.5 mammarytumor cell line was injected into the left cardiacventricle of immunotolerant transgenic neu-N mice and athymic nu/nu mice....
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