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Cancer Gene Therapy

Researchers from Hiroshima University report on findings in cancer gene therapy

Published in Cancer Weekly, October 21st, 2008

According to recent research from Japan, "This study was undertaken to investigate the radiosensitizing effects of fibroblast growth factor receptor 2IIIb (FGFR2IIIb) in androgen-independent human prostate carcinoma PC-3 cells devoid of normally resident epithelial cell FGFR2IIIb. A clonal line of PC-3 cells expressing FGFR2IIIb was established by stable transfection."

"Clonogenic cell survival, apoptosis and cell cycle distribution with and without gamma-irradiation were then compared between FGFR2IIIb-expressing PC-3 cells and control cells mock-transfected with vector alone. Gamma-irradiation resulted in an increase of clonogenic cell death concurrent with enhanced...

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