Cancer Weekly
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Breast Cancer
New findings from J.R. Pasqualini and co-authors in the area of breast cancer published
October 21st, 2008
According to recent research from Paris, France, "Progesterone is metabolized in the normal breast mainly into 4-ene-pregnenes (e.g. 20 alpha-dihydroprogesterone, 20 alpha DHP) but, in contrast, in breast cancer tissue the 5 alpha-dihydropregnanes (e.g. 5 alpha-dihydroprogesterone, 5 alpha DHP) are prevalent. In the present study the effect of progesterone and its, main metabolites 20aDHP and 5aDHP on the aromatase activity in a stable aromatase-expressing estrogen receptor-positive human breast cancer cell line, MCF-7aro, was explored." "The MCF-7aro cells were stripped of endogenous steroids and incubated with physiological concentrations of [H-3]-testosterone...
Source: Cancer Weekly (2008-10-21)
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