Cancer Weekly
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Breast Cancer
Recent findings in breast cancer described by I. Bernardpierrot and colleagues
October 21st, 2008
According to a study from Paris, France, "The 8p11-12 chromosome region is one of the regions most frequently amplified in breast carcinoma (10-15% of cases). Several genes within this region have been identified as candidate oncogenes, as they are both amplified and over-expressed." "However, very few studies have explored the role of these genes in cell transformation, with the aim of identifying valuable therapeutic targets. An analysis of comparative genomic hybridization array and expression profiling data for a series of 152 ductal breast carcinomas and 21 cell lines identified five genes (LSM1, BAG4, DDHD2, PPAPDC1B, and WHSC1L1) within the amplified region as...
Source: Cancer Weekly (2008-10-21)
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