Cancer Weekly
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Breast Cancer
Research in the area of breast cancer reported from K. Honma and colleagues
October 21st, 2008
According to a study from Tokyo, Japan, "Drug resistance acquired by cancer cells has led to treatment failure. To understand the regulatory network underlying docetaxel resistance in breast cancer cells and to identify molecular targets for therapy, we tested small interfering RNAs (siRNAs) against 36 genes whose expression was elevated in human nonresponders to docetaxel for the ability to promote apoptosis of docetaxel-resistant human breast cancer cells (MCF7-ADR cells)." "The results indicate that the downregulation of the gene encoding ribopholin II (RPN2), which is part of an N-oligosaccharyl transferase complex, most efficiently induces apoptosis of MCF7-ADR...
Source: Cancer Weekly (2008-10-21)
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