Cancer Weekly
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Immunotherapy
New immunotherapy findings from Third Military Medical University described
October 28th, 2008
"Peptide vaccination for cancer immunotherapy requires identification of peptide epitopes derived from antigenic proteins associated with tumors. Heparanase (Hpa) is broadly expressed in various advanced tumors and seems to be an attractive new tumor-associated antigen," scientists in Chongqing, People's Republic of China report. "The present study was designed to predict and identify HLA-A2-restricted cytotoxic T lymphocyte (CTL) epitopes in the protein of human Hpa. For this purpose, HLA-A2-restricted CTL epitopes were identified using the following four-step procedure: 1) a computer-based epitope prediction from the amino acid sequence of human Hpa, 2) a...
Source: Cancer Weekly (2008-10-28)
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