Cancer Weekly
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Cancer Gene Therapy
Investigators at University of Michigan release new data on cancer gene therapy
October 28th, 2008
"Antiangiogenic therapies have shown varying results partly because each tumor type secretes a distinct panel of angiogenic factors to sustain its own microvascular network. In addition, recent evidence demonstrated that tumors develop resistance to antiangiogenic therapy by turning on alternate angiogenic pathways when one pathway is therapeutically inhibited," scientists in the United States report. "Here, we test the hypothesis that expression of a caspase-based artificial death switch in tumor-associated endothelial cells will disrupt tumor blood vessels and slow down tumor progression irrespective of tumor type. Adenoviral vectors expressing inducible Caspase-9...
Source: Cancer Weekly (2008-10-28)
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