Cancer Weekly
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Vaccines
Study results from McMaster University broaden understanding of vaccines
October 28th, 2008
According to recent research from Hamilton, Canada, "In vitro manipulated dendritic cells (DC have increasingly been used as a promising vaccine formulation against cancer and infectious disease. However, improved understanding of the immune mechanisms is needed for the development of safe and efficacious mucosal DC immunization." "We have developed a murine model of respiratory mucosal immunization by using a genetically manipulated DC vaccine. Within 24 h of intranasal delivery, the majority of vaccine DCs migrated to the lung mucosa and draining lymph nodes and elicited a significant level of T cells capable of IFN-gamma secretion and CTL in the airway lumen as well...
Source: Cancer Weekly (2008-10-28)
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