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Apoptosis Gene Therapy
Researchers from Kanazawa University, Cancer Research Institute describe findings in apoptosis gene therapy
October 28th, 2008
Current study results from the report, 'Tumor cell apoptosis induces tumor-specific immunity in a CC chemokine receptor 1- and 5-dependent manner in mice,' have been published. "The first step in the generation of tumor immunity is the migration of dendritic cells (DCs) to the apoptotic tumor, which is presumed to be mediated by various chemokines. To clarify the roles of chemokines, we induced apoptosis using suicide gene therapy and investigated the immune responses following tumor apoptosis," scientists writing in the Journal of Leukocyte Biology report. "We injected mice with a murine hepatoma cell line, BNL 1ME A.7R.1 (BNL), transfected with HSV-thymidine...
Source: Cancer Weekly (2008-10-28)
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