Cancer Weekly
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Cancer Gene Therapy
Study results from S. Toffanin et al provide new insights into cancer gene therapy
October 28th, 2008
Fresh data on cancer gene therapy are presented in the report 'Clusterin: a potential target for improving response to antiestrogens.' "Antiestrogens represent the first line of therapy in the treatment of estrogen receptor-positive (ER+) breast cancer patients. Unfortunately, up to 40% of patients develop resistance associated with progression and frequently die for metastatic breast cancer," investigators in Milano, Italy report. "The molecular events leading to pharmacological resistance are not completely understood. We attempted to verify in an experimental model the role of cytoplasmic clusterin (CLU), a cytoprotective protein found to be up-regulated in...
Source: Cancer Weekly (2008-10-28)
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