Life Sciences

Studies from McGill University provide new data on life sciences

Published in Cancer Weekly, October 28th, 2008

" Statins can ameliorate atherosclerosis by inhibition of cholesterol biosynthesis or by modulation of inflammation. In earlier work, we showed that homocysteine (Hcy) reduced synthesis of apolipoprotein A-I (ApoA-I)," scientists writing in the journal Cardiovascular Research report.

"Our goal in this study was to determine whether Hcy could interfere with the ability of simvastatin to increase ApoA-I synthesis or to modify statin-dependent regulation of inflammatory factors. Methods and results Human HepG2 hepatocarcinoma cells and murine RAW264.7 macrophages were treated with simvastatin, with and without Hcy, to examine the expression of ApoA-I and nuclear...

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Source: Cancer Weekly (2008-10-28)

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