Cancer Weekly
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Cancer Gene Therapy
Research from Johns Hopkins University, Medical Department provide new insights into cancer gene therapy
October 28th, 2008
According to recent research from the United States, "We have developed a hypoxia-inducible gene therapy approach for the expression of the mature form of human endonuclease G to facilitate cell death in hypoxic regions of the tumor. The chimeric therapeutic gene is placed under the control of a hypoxia response element based promoter and contains a translocation motif linked in frame to an oxygen-dependent degradation domain and the endonuclease G gene." "Transient expression of the chimeric therapeutic gene in breast and prostate cancer cell lines resulted in efficient cell death under hypoxia-mimetic conditions. Stable MDA-MB-435 cells expressing the chimeric...
Source: Cancer Weekly (2008-10-28)
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