Cancer Weekly
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Angiogenesis
New research on angiogenesis from National Institutes of Health summarized
October 28th, 2008
According to recent research published in the journal Neoplasia, "Nitric oxide ( NO) plays important physiological roles in the vasculature to regulate angiogenesis, blood flow, and hemostasis. In solid tumors, NO is generally acknowledged to mediate angiogenic responses to several growth factors." "This contrasts with conflicting evidence that NO can acutely increase tumor perfusion through local vasodilation or diminish perfusion by preferential relaxation of peripheral vascular beds outside the tumor. Because thrombospondin 1 (TSP1) is an important physiological antagonist of NO in vascular cells, we examined whether, in addition to inhibiting tumor...
Source: Cancer Weekly (2008-10-28)
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