Cancer Weekly
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Apoptosis
Research on apoptosis discussed by scientists at Cincinnati Children's Hospital
October 28th, 2008
According to recent research from the United States, "Nucleophosmin (NPM) is frequently over-expressed in leukemias and other tumors. NPM has been reported to suppress oncogene-induced senescence and apoptosis and may represent a therapeutic target for cancer." "We fused a NPM-derived peptide to the HIV-TAT (TAT-NPM Delta C) and found that the fusion peptide inhibited proliferation and induced apoptotic death of primary fibroblasts and preleukemic stem cells. TAT-NPM Delta C down-regulated several NF-kappa B-controlled survival and inflammatory proteins and suppressed NF-kappa B-driven reporter gene activities. Using an inflammation-associated leukemia model, we...
Source: Cancer Weekly (2008-10-28)
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