Cancer Weekly
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Apoptosis
Studies from Boston University, Medical Department update current data on apoptosis
October 28th, 2008
"The p27(Kip1) (p27) cyclin-dependent kinase inhibitor and c-Myc oncoprotein play essential roles in control of cell cycle progression and apoptosis. Induction of p27(CDKN1B) gene transcription by Forkhead box 0 proteins Such as FOXO3a leads to growth arrest and apoptosis," investigators in the United States report. "Previously, we observed that B cell receptor (surface IgM) engagement of WEHI 231 immature B lymphoma cells with an anti-IgM antibody results in activation of FOXO3a, growth arrest and apoptosis. As ectopic c-Myc expression in these cells prevented anti-IgM induction of p27 and cell death, we hypothesized that c-Myc represses FOXO3a-mediated transcription....
Source: Cancer Weekly (2008-10-28)
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