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Cancer Gene Therapy
Studies from Third Military Medical University describe new findings in cancer gene therapy
October 28th, 2008
According to a study from Chongqing, People's Republic of China, "Apurinic/apyrimidinic endonuclease (APE1), a bifunctional AP endonuclease/redox factor, is important in DNA repair and redox signaling, may be associated with radioresistance. Here we investigate whether targeted inhibition of APE1 can sensitize tumor cells to irradiation in vitro and in vivo." "We first constructed chimeric adenoviral vector Ad5/F35 carrying human APE1 siRNA (Ad5/F35-APE1 siRNA). The infectivity of chimeric Ad5/F35 to LOVO colon cancer cells was greater than that of Ad5. APE1 was strongly expressed and nuclear factor kappa B (NF-kappa B), a downstream molecule of APE1, known as a...
Source: Cancer Weekly (2008-10-28)
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