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Life Sciences
Research findings from J. Gruenewald et al update understanding of life sciences
November 4th, 2008
"The ability to selectively induce a strong immune response against self-proteins, or increase the immunogenicity of specific epitopes in foreign antigens, would have a significant impact on the production of vaccines for cancer, protein-misfolding diseases, and infectious diseases. Here, we show that site-specific incorporation of an immunogenic unnatural amino acid into a protein of interest produces high-titer antibodies that cross-react with WT protein," investigators in the United States report. "Specifically, mutation of a single tyrosine residue (Tyr(86)) of murine tumor necrosis factor-alpha (mTNF-alpha) to p-nitrophenylaianine (pNO(2)Phe) induced a high-titer...
Source: Cancer Weekly (2008-11-04)
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