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Gene Therapy
Recent findings from University of Rostock, Department of Medicine highlight research in gene therapy
November 4th, 2008
Scientists discuss in 'Molecular insights into connective tissue growth factor action in rat pancreatic stellate cells' new findings in gene therapy. "Pancreatic fibrosis, a key feature of chronic pancreatitis and pancreatic cancer, is mediated by activated pancreatic stellate cells (PSC). Connective tissue growth factor (CTGF) has been suggested to play a major role in fibrogenesis by enhancing PSC activation after binding to alpha5beta1 integrin," scientists in Rostock, Germany report. "Here, we have focussed on molecular determinants of CTGF action. Inhibition of CTGF expression in PSC by siRNA was associated with decreased proliferation, while application of...
Source: Cancer Weekly (2008-11-04)
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