Cancer Weekly
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Adenovirus
New findings from F.M. Cardoso and co-researchers in the area of adenovirus described
November 4th, 2008
According to a study from Cuernavaca, Mexico, "It is well established that the human subgroup C C adenovirus type 5 (Ad5) E1B 55 kDa protein can regulate the activity and concentration of the cellular tumor Suppressor, p53. However, the contribution(s) of these functions of the E1B protein to viral reproduction remains unclear To investigate this issue, we examined properties of p53 ill normal human cells infected by El R mutant viruses that display defective entry into the late phase or viral late mRNA export." "The steady-state concentrations of p53 were significantly higher in cells infected by the E1B 55 kDa null mutant Hr6 or three mutants carrying small insertions...
Source: Cancer Weekly (2008-11-04)
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