Cancer Weekly
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Angiogenesis
Studies from Columbus Children's Hospital provide new data on angiogenesis
November 4th, 2008
"Tumor blood vessels exhibit abnormal structure and function that cause disturbed blood flow and high interstitial pressure, which impair delivery of anti-cancer agents. Past efforts to normalize the tumor vasculature have focused on inhibition of soluble angiogenic factors, such as VEGF; however, capillary endothelial (CE) cell growth and differentiation during angiogenesis are also influenced by mechanical forces conveyed by the extracellular matrix (ECM)," researchers in the United States report. "Here, we explored the possibility that tumor CE cells form abnormal vessels because they lose their ability to sense and respond to these physical cues. These studies...
Source: Cancer Weekly (2008-11-04)
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