Cancer Weekly
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Angiogenesis
Studies from M. Arakawa and colleagues reveal new findings on angiogenesis
November 4th, 2008
According to recent research from Miyamoto, Japan, "Angiogenesis is a critical step for the tumor therapy. Many angiogenic factors are involved in the tumor angiogenesis." "In the course Of Our screening for inhibitors of angiogenin secretion, one of angiogenic factors, we have isolated a new terrein glucoside (1) and terrein (2) from the fermentation broth of fungal strain Aspergillus sp. PF1381. The structure and absolute stereochemistry of I was determined to be (4S,5R)-5-[(alpha-D-glucopyranosyl)oxy]-4-hydroxy-3-(E-1-propenyl)-2-cyclopenten-1-one on the basis of spectral and enzymatic analyses. Compounds I and 2 equally inhibited angiogenin secretion frorn...
Source: Cancer Weekly (2008-11-04)
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