Cancer Weekly
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Angiogenesis
Studies from University of Turin in the area of angiogenesis published
November 4th, 2008
"Increased evidence suggests that cancer-associated inflammation supports tumor growth and progression. We have previously shown that semaphorin 4D (Sema4D), a ligand produced by different cell types, is a proangiogenic molecule that acts by binding to its receptor, plexin B1, expressed on endothelial cells (Conrotto, P., D. Valdembri, S. Corso, G. Serini, L. Tamagnone, P. M. Comoglio, F. Bussolino, and S. Giordano. 2005. Blood. 105: 4321-4329)," scientists in Turin, Italy report. "The present work highlights the role of Sema4D produced by the tumor microenvironment on neoplastic angiogenesis. We show that in an environment lacking Sema4D, the ability of cancer cells to...
Source: Cancer Weekly (2008-11-04)
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